م. رجاء صيهود عباس / Hesperidin improves fertility in female mice infected by Brucella melitensis

ABSTRACT
The present study was designed to improve fertility in female mice caused by virulent strain of Brucella melitensis. Sixty female mice were divided into 5 groups equally: Group1 giving normal saline 0.3 ml orally serve as control negative. Group2 served as control positive infected with a virulent strain of B. melitensis(1×108) CFU/ ml I/P. Group 3 administrated hesperidin 10mg /kg B.W. group 4 infected with B. melitensisand treated with hesperidin 10mg/kg B.W. Group 5 treated with hesperidin 10mg /kg B.W. and infected with B. melitensis(1×108). At thirty and sixty days of the experiment (half and end of the experiment), six mice from each group were sacrificed to determine serum hormones (FSH, LH, estrogen, and progesterone). The results revealed that hesperidin reduces estrogen-progesterone levels and
increases levels of FSH and LH in comparison with an infected group (G2) serum levels of estrogen, progesterone was high and FSH and LH were low levels. This study concluded that hesperidin improves fertility because of act as anti-cancer, anti-oxidant anti-inflammatory action that giving protect of female reproductive organs of female mice in comparison with infected mice with B. melitensiswhich caused a different change of hormonal levels that lead to cause infertility

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