د. رشد اياد عبدالحميد/Circulating miRNA-21-5p role in the development of orbitopathy in Graves disease

Abstract

Background

The pathogenesis of graves orbitopathy (GO) is complex, with genetic predisposition, environmental factors and epigenetic alterations. Understanding the role of epigenetics including noncoding microribonucleic acids (miRNAs) can give a new information about the pathogenesis and clinical features of disease due to the modulatory effects in the immune system, such as miR-21-5p which affect the balance of T-regulatory (Treg)/Th17 cells. This study was designed to evaluate how the circulating miR-21-5p is involved in the development of orbitopathy in Graves disease (GD) and to assess its diagnostic value.

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