1

د.اسراء ايوب علوان / The extent of UMOD gene polymorphism and its level in type 2 diabetes patients

Abstract
Background & objectives: Uromodulin is a protein produced only in cells of the kidney tubular and get out with urine. Some the mutations which lead to uromodulin is folding leads to retention in the kidney, and that promote the immune response to the system to cause infection of the kidney disease such as diabetic nephropathy (DN), that is one of the kidney diseases occurring as a result of diabetes. Our study found accompanied by rs4293393 variation of the UMOD gene as well as the susceptibility to renal illness in patients experiencing Type-2 diabetes mellitus. Methods: 100 samples are including 50 with diabetes and 50 healthy controls, are genotyped for UMOD variant rs4293393T>C via RT-PCR. ELISA tested the uromodulin concentration. In addition, the uric acid, creatinine and urea concentration were performed via auto analyserA15 Biosystems instrument.